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. 2020 Oct 31;8(11):465. doi: 10.3390/biomedicines8110465

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Clinical relevance of FAM188B expression in lung adenocarcinoma patients and a proposed model for an oncogenic role of FAM188B via FOXM1 regulation. (A) Immunohistochemical analysis of levels of FAM188B, FOXM1, and β-catenin in lung cancer tissues and normal lung tissues. Images of in each set were taken at 10× (left panel, scale bar; 200 μm) and boxed areas were magnified at 40× (right panel, scale bar; 50 μm). (B) Oncomine survey of significantly different copy number unit number between normal vs. cancer in TCGA lung 2 (p = 7.85 × 10⁻²⁸). (C) Overall survival curves for lung cancer patients with (red line) or without (blue line) FAM188B alteration from TCGA Firehose LUAD (n = 586) dataset (p = 0.0140). (D) Schematic proposed model of FAM188B in association with FOXM1 regulation.