Table 3.
Effects of linalool and cisplatin on the markers of oxidative stress in kidney tissues of rats.
| Treated Groups | GSH (μmol/g Tissue) |
SOD (U/mg Protein) |
CAT (nmol/g Tissue) |
MDA (nmol/g Tissue) |
NADPH (ng/mg Protein) |
|---|---|---|---|---|---|
| Normal | 2.91 ± 0.12 | 16.22 ± 2.84 | 22.70 ± 0.66 | 12.20 ± 0.96 | 1.39 ± 0.35 |
| Linalool | 2.75 ± 0.26 | 19.48 ± 1.99 | 24.03 ± 0.87 | 14.43 ± 0.81 | 1.77 ± 0.67 |
| Cisplatin | 0.56 ± 0.08 # | 3.06 ± 0.69 # | 83.23 ± 5.34 # | 92.83 ± 6.17 # | 9.24 ± 0.88 # |
| Cisplatin +linalool (50 mg/kg) | 1.97 ± 0.31 * | 11.03 ± 1.04 * | 34.40 ± 6.6 * | 34.96 ± 3.04 * | 2.46 ± 0.72 * |
| Cisplatin +linalool (100 mg/kg) | 2.27 ± 0.51 *,@ | 13.87 ± 1.31 *,@ | 28.65 ± 3.73 *,@ | 30.64 ± 2.15 * | 2.01 ± 0.68 * |
All values are expressed as mean ± SD. #, statistically significant from normal control group, *, statistically significant from cisplatin -only group, @, statistically significant from cisplatin + linalool 50 mg/kg group (p < 0.05) using one-way ANOVA followed by Tukey’s test as a post-hoc analysis.