Table 3.

KEGG pathways enriched by genes targeted by the 14 candidate miRNAs (cancer pathways are not included).

miRNA(s)	KEGG Pathways	Total	Targeted	p	Padjust
n =14	Mitophagy	63	15	6.92 × 10−5	0.02095 *
n =14	Axon guidance	180	29	1.25 × 10−4	0.01896 *
n =13	Regulation of actin cytoskeleton	217	28	5.19 × 10−3	0.39371
n =13	MAPK signaling pathway	294	35	7.12 × 10−3	0.35967
n =14	Phosphatidylinositol signaling system	98	15	8.12 × 10−3	0.35154
n =14	Inositol phosphate metabolism	73	12	9.76 × 10−3	0.36990
n =13	TNF signaling pathway	110	16	0.01036	0.34905
n =13	Autophagy	130	18	0.01122	0.34022
n =13	Wnt signaling pathway	160	21	0.01180	0.32508
n =14	mTOR signaling pathway	154	20	0.01532	0.30952
n =12	AGE-RAGE signaling pathway in diabetic complications	101	14	0.02327	0.37114
n =13	Neurotrophin signaling pathway	121	16	0.02408	0.34750
n =13	Protein processing in endoplasmic reticulum	163	20	0.02671	0.36798
n =14	Endocytosis	269	30	0.02725	0.35904
n =12	Cellular senescence	185	22	0.02868	0.36211
n =13	Calcium signaling pathway	189	22	0.03532	0.42808
n =12	Lysine degradation	59	9	0.03634	0.42351
n =13	Ubiquitin mediated proteolysis	138	17	0.03756	0.42161
n =14	Insulin signaling pathway	139	17	0.03984	0.43120
n =13	Progesterone-mediated oocyte maturation	90	12	0.04402	0.44468
n =12	FoxO signaling pathway	132	16	0.04835	0.472584

* Pathways with strongest statistical support for enrichment, with genes targeted by 14 out of 14 candidate miRNAs.