Table 1.

Pharmacovigilance test in pharmacocosmetics ¹.

Toxicity Test	Genotoxicity Test	Efficacy Trials	Other Tests
Eye irritation (Invittox hemolysis test n 37, Model test of reconstituted human skin, Fluorescein leakage test method) Dermal irritation OECD 439 Dermal corrosion OECD 431; OECD 435 Nasal irritation Oral irritation Phototoxicity OECD 432 Cytotoxicity (MTT, XTT, Neutral red, Alamar Blue, LDH, MTS, Wst-8)	Ames test OECD 471 Mouse lymphoma assay OECD 476 Micronucleus test OECD 487 Comet assay	Cleaning efficacy Anti-angiogenic efficacy Anti-inflammatory efficacy Antioxidant efficacy Cell proliferation assay Cell cohesion test Anti-itch efficacy Lipolytic efficacy Collagen synthesis enhancement test Elastin synthesis test β-defensin synthesis increase assay Epidermal protease release assay Metalloprotease decrease assay Anti-growth factor action test Test of decrease in levels of human cathelicidin Healing efficacy Thermo-protective efficacy Reparative and regenerative efficacy Efficacy of anti-protective against dryness Moisturizing efficacy Antimicrobial efficacy	Percutaneous absorption and penetration OECD 428 Challenge test Microbiological controls Determination of active ingredients by chromatography Development and validation of analytical methods Nanotoxicology

¹ Tests carried out to evaluate efficacy and toxicity of drugs and cosmetics: toxicity test, genotoxicity test, irritation test and other tests carried out.