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. 2020 Nov 12;25(22):5281. doi: 10.3390/molecules25225281

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of PIP3-dependent Akt translocation and InsP₅ competition mechanism. RTK, receptor tyrosine kinase; PIP2, PtdIns(4,5)P₂; PIP3, PtdIns(3,4,5)P₃; PI3K, Phosphoinositide 3-kinase; IP5, inositol pentakisphosphate; PH pleckstrin homology domain.