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. 2020 Nov 12;12(11):1086. doi: 10.3390/pharmaceutics12111086

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Forest plot showing probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain in local drug delivery and adjunctive agents (LDAs) vs. subgingival mechanical debridement (SMD) alone in split-mouth studies. (B) Forest plot showing PPD reduction and CAL gain in LDAs vs. SMD alone in parallel studies. The P-score indicates the treatment’s probability in ranking the best in efficacy in the network. The dotted line represents the threshold for clinical significance.