Table 1.
Characteristics of different adipocyte tissues.
| White Adipocytes (WAT) | Brown Adipocytes (BAT) | Beige Adipocytes * (Cold, TZD, FGF21, IL-4, IL-6) | ||
|---|---|---|---|---|
| Fatty Ac Oxidation (+) | Fatty Ac Oxidation (+++) | Fatty Ac Oxidation (+) |
|
Fatty Ac Oxidation (+++) |
| Lipid Storage (+++) | Lipid Storage (+) | Lipid Storage (+++) |
|
Lipid Storage (+) |
| Mitochondria (+) | Mitochondria (+++) | Mitochondria (+) |
|
Mitochondria (+++) |
| PGC-1α (+) | PGC-1α (+++) | PGC-1α (+) |
|
PGC-1α (+++) |
| Respiratory Chain (+) | Respiratory Chain (+++) | Respiratory Chain (+) |
|
Respiratory Chain (+++) |
| Succinate (+) | Succinate (+++) | Succinate (+) |
|
Succinate (+++) |
| UCP1 (-) | UCP1 (+++) | UCP1 (-) |
|
UCP1 (+++) |
| Unilocular | Multilocular | Unilocular |
|
Multilocular |
| Markers: ASC-1, Resistin, Leptin | Markers: Eva1, Lhx8, Zic1 | Markers: CD137, CIDEA, Cited, SLIT2, Tbx, Tmem26, | ||
* Some conditions that can induce thermogenic activity of beige adipocytes. ASC-1, adipocyte-specific cell surface protein-1; CIDEA, cell death-inducing DFFA-like effector; CD 137, cluster of differentiation 137; Cited1, Cbp/P300-interacting transactivator 1; Eva1, epithelial V-like antigen 1; FABP4, fatty acid binding protein 4; FGF21, fibroblast growth factor 21; Lhx8, LIM/homeobox protein; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator alpha 1; Pdk4, pyruvate dehydrogenase kinase 4; SLIT2, slit guidance ligand 2; Tbx1,T-box transcription factor 1; Tmem2, transmembrane protein 26; TZD, thiazolidinedione; UCP1, uncoupling protein 1; Zic1, zinc finger protein 1. (+) increase; (+++) highest increase; (-) reduce; () Changes in Beige adipocytes after browning.