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Thioredoxin reductase 1 activity was assayed by measuring NADPH-dependent reduction of DTNB at 412 nm; IC50 values were calculated by a four parameter logistic model (p < 0.05).
| Compound | IC50 (nM) |
|---|---|
| [HB(pz)3]Ag(PTA) (1) | 2.8 |
| [HB(pz)3]Ag(DAPTA) (2) | 3.5 |
| [HB(pz)3]Ag (PTA-SO2) (3) | 2.6 |
| [HB(pz)3]Ag(PCN) (4) | 2.7 |
| [HB(pz)3]Ag(PPh3) (5) | 3.3 |
| [Ag(PTA)4]BF4 (6) | 9.3 |
| [Ag(DAPTA)4]BF4 (7) | 7.2 |
| [Ag(PTA-SO2)4]BF4 (8) | 16.8 |
| [Ag(PCN)2]BF4 (9) | 2.4 |
| [Ag(PPh3)4]BF4 (10) | 3.2 |
| AgNO3 | 2.4 |
| Auranofin | 0.8 |
