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. Author manuscript; available in PMC: 2021 Mar 10.
Published in final edited form as: Nature. 2020 Sep 10;587(7835):673–677. doi: 10.1038/s41586-020-2749-z

Figure 3. Interactions between cGAS and the nucleosome.

Figure 3.

a. cGAS binds to the acidic patch of the nucleosome. cGAS is shown by the green ribbons. The histone core is shown by the surface representation colored according to surface electrostatic potential. Positively charged surface is colored in blue and negatively charged surface in red.

b. Interactions between cGAS (green) and histone H2A (cyan) and H2B (slate).

c. Superposition of the cGAS-dsDNA and the cGAS-nucleosome complex structures shows that the second DNA binding site (site B) of cGAS mediates its interactions with the nucleosome.

d. Two overlapping sets of residues are involved in nucleosome and DNA binding by cGAS.