Figure 10. Acute MeHg exposure-induced increases of Ca²⁺_i in hiPSC-MN are mediated in part by AMPA/KA receptors.

MeHg-induced increase in fluorescence time-to-onset is delayed by exposure to 20 μM CNQX, an AMPA/KA receptor antagonist, showing that this receptor is contributing to MeHg-induced increases in [Ca²⁺]_i in hiPSC-MNs. (#) indicates significant difference between 0.5 μM versus 1.0 μM and 1.5 μM (p ≤ 0.05) as determined by Two-Way ANOVA and Bonferroni’s post hoc test. Values are represented as mean ± SEM (n ≥ 4). When not shown, the SEM is less than the diameter of the error bar.