Table 1.
Characteristics of regions-of-interest (ROIs) and regions-of-exclusion (ROEs).
| Total Tissue Area (mm2) | Regions-of-Interest (ROIs) | Regions-of-Exclusion (ROEs) |
||||
|---|---|---|---|---|---|---|
| Mean (±SD) | ||||||
| Relative Area (%) | p-Val | |||||
| Mean (±SD) | ||||||
|
ControlOrgans
(n = 5) |
Fibrotic Organs 1
(n = 5) |
|||||
| Liver | 43.3 (13.9) | Perivascular tissue | 1.20 (0.32) | 1.92 (0.70) | 0.007 | Capsule |
| Bridges | 0.04 (0.02) | 2.79 (0.30) | <0.001 | Large lumens | ||
| Parenchyma | 98.76 (0.30) | 95.29 (0.84) | <0.001 | |||
| Lung | 32.77 (6.18) | Peri-air ducts tissue | 4.22 (0.39) | 4.24 (0.81) | 0.950 | Pleura |
| Perivascular tissue | 2.94 (0.78) | 2.93 (0.45) | 0.992 | Dense peri-air duct connective tissue (variable) 2 | ||
| Parenchyma | 92.85 (0.95) | 92.83 (1.01) | 0.973 | Large lumens & arteries | ||
| Kidney | 17.63 (1.73) | Inner medulla | 4.46 (1.15) | 6.49 (3.07) | 0.204 | Capsule |
| Outer medulla | 10.88 (2.32) | 13.03 (2.61) | 0.205 | Hilum | ||
| Cortex | 84.66 (1.78) | 80.48 (2.81) | 0.022 | Large lumens | ||
1 Last time point of treatment (liver: 7w CCl4; lung: BLM-chronic; kidney: 4w CIS). 2 Strongly stained fibers surrounding very large air ducts were included in the total tissue area but not considered as a ROI. This region represented 5.02% (1.42) and 6.46% (2.12) of the total tissue area (p > 0.05).