Skip to main content
Springer Nature - PMC COVID-19 Collection logoLink to Springer Nature - PMC COVID-19 Collection
. 2020 Dec 1;5(56):2839–2851. doi: 10.1557/adv.2020.418

Novel Antimicrobial Surfaces to Defeat COVID-19 Transmission

Rodica Cristescu 11,, Roger J Narayan 21, Douglas B Chrisey 31
PMCID: PMC7711331  PMID: 33425377

Abstract

Antimicrobial surface coatings function as a contact biocide and are extensively used to prevent the growth and transmission of pathogens on environmental surfaces. Currently, scientists and researchers are intensively working to develop antimicrobial, antiviral coating solutions that would efficiently impede/stop the contagion of COVID-19 via surface contamination. Herein we present a flavonoid-based antimicrobial surface coating fabricated by laser processing that has the potential to eradicate COVID-19 contact transmission. Quercetin-containing coatings showed better resistance to microbial colonization than antibiotic–containing ones.

References

  • [1].Xu S, Li Y. The Lancet. 2020;395:1321–1322. doi: 10.1016/S0140-6736(20)30845-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [2].World Coronavirus Statistics (2020). Available at: https://www.worldometers.info/coronavirus/ (accessed 17 September 2020).
  • [3].Pushpakom S, Iorio F, Eyers PA, Escott KJ, Hopper S, Wells A, Doig A, Guilliams T, Latimer J, McNamee C, Norris A. Nat. Rev. Drug Discov. 2019;18:41. doi: 10.1038/nrd.2018.168. [DOI] [PubMed] [Google Scholar]
  • [4].Abian O, Ortega-Alarcon D, Jimenez-Alesanco A, Ceballos-Laita L, Vega S, Reyburn HT, Rizzuti B, Velazquez-Campoy A. Int. J. Biol. Macromol. 2020;164:1693. doi: 10.1016/j.ijbiomac.2020.07.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [5].Rawson TM, Ming D, Ahmad R, More LSP, Holmes AH. Nat. Rev. Microbiol. 2020;18:409. doi: 10.1038/s41579-020-0395-y. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [6].Spitzer M, Robbins N, Wright GD. Virulence. 2017;8:169–185. doi: 10.1080/21505594.2016.1196300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • [7].Tyers M, Wright GD. Nat. Rev. Microbiol. 2019;17:141–155. doi: 10.1038/s41579-018-0141-x. [DOI] [PubMed] [Google Scholar]
  • [8].McGill RA, Chrisey DB. Method of producing a film coating by matrix assisted pulsed laser deposition. 2000. [Google Scholar]
  • [9].Chrisey DB, McGill RA, Horwitz JS, Pique A, Ringeisen BR, Bubb DM, Wu PK. Chem. Rev. 2003;103:553. doi: 10.1021/cr010428w. [DOI] [PubMed] [Google Scholar]
  • [10].M.A Farha and E.D Brown, Nat. Microbiol.4, 565 (2019). [DOI] [PubMed]
  • [11].Cristescu R, Surdu AV, Grumezescu AM, Oprea AE, Trusca R, Vasile O, Dorcioman G, Visan A, Socol G, Mihailescu IN, Mihaiescu D, Enculescu M, Chifiriuc MC, Boehm RD, Narayan RJ, Chrisey DB. Appl. Surf. Sci. 2015;336:234. doi: 10.1016/j.apsusc.2014.11.145. [DOI] [Google Scholar]
  • [12].Cristescu R, Visan A, Socol G, Surdu AV, Oprea AE, Grumezescu AM, Chifiriuc MC, Boehm RD, Yamaleyeva D, Taylor M, Narayan RJ, Chrisey DB. Appl. Surf. Sci. 2016;374:290. doi: 10.1016/j.apsusc.2015.11.252. [DOI] [Google Scholar]
  • [13].Yu Q, Wu Z, Chen H. Acta Biomater. 2015;16:1–13. doi: 10.1016/j.actbio.2015.01.018. [DOI] [PubMed] [Google Scholar]
  • [14].Lazar V, Chifiriuc CM. Roum. Arch. Microbiol. Immunol. 2010;69:95–107. [PubMed] [Google Scholar]
  • [15].Yuan L, Yu Q, Li D, Chen H. Macromol. Biosci. 2011;11:1031. doi: 10.1002/mabi.201000464. [DOI] [PubMed] [Google Scholar]
  • [16].Negut I, Visan AI, Popescu CE, Cristescu R, Ficai A, Grumezescu AM, Chifiriuc MC, Boehm RD, Yamaleyeva D, Taylor M, Narayan RJ, Chrisey DB. Appl. Sci. 2019;9:786–798. doi: 10.3390/app9040786. [DOI] [Google Scholar]
  • [17].Mortale SP, Karuppayil SM. Am. J. Clin. Microbiol. Antimicrob. 2018;1:1022. [Google Scholar]
  • [18].Andrew S, Hitchcock CA, Dorr PK. Antifungal compositions comprising voriconazole and trovafloxacin or prodrugs thereof. 2000. [Google Scholar]
  • [19].Sun L, Liao K, Li Y, Zhao L, Liang S, Guo D, Hu J, Wang D. J Nanosci. Nanotechnol. 2016;16:2325–2335. doi: 10.1166/jnn.2016.10934. [DOI] [PubMed] [Google Scholar]
  • [20].Gainer K. Global Markets for Drug-Device Combinations (PHM045D) 2015. [Google Scholar]
  • [21].Lehr P. Global Markets for Rapid Medical Diagnostic Kits (HLC007H) Wellesley: BCC Research; 2013. [Google Scholar]
  • [22].Elder M. Market Research Report. Point of Care Diagnostics (HLC043C) Wellesley: BCC Research; 2012. [Google Scholar]

Articles from Mrs Advances are provided here courtesy of Nature Publishing Group

RESOURCES