Skip to main content
Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2020 Nov 14:piaa148. doi: 10.1093/jpids/piaa148

SARS-CoV-2 triggering severe ARDS and secondary HLH in a 3-year-old child with Down syndrome

Sarah Kim-Hellmuth 1,#, Matthias Hermann 2,#, Julia Eilenberger 1, Julia Ley-Zaporozhan 3, Marcus Fischer 2, Fabian Hauck 1, Christoph Klein 1,4, Nikolaus Haas 2, Matthias Kappler 1, Johannes Huebner 1,4, André Jakob 2, Ulrich von Both 1,4,
PMCID: PMC7717321  PMID: 33188394

Abstract

Down syndrome (DS) predisposes to severe immunologic reaction secondary to infectious triggers. Here we report a paediatric DS patient with COVID-19 who developed a hyperinflammatory syndrome, severe ARDS and secondary HLH requiring PICU admission and treatment with steroids, IVIG and Remdesivir. Investigations into genetic susceptibilities for COVID-19 and SARS-CoV-2-associated complications warrants systematic clinical and scientific studies.

Keywords: Down syndrome, hyperinflammation, sHLH, Remdesivir, paediatrics


Articles from Journal of the Pediatric Infectious Diseases Society are provided here courtesy of Oxford University Press

RESOURCES