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. 2020 Nov 18:jiaa724. doi: 10.1093/infdis/jiaa724

Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19

Anne-Sophie Bedin 1,✉, Alain Makinson 2, Marie-Christine Picot 3, Frank Mennechet 1, Fabrice Malergue 4, Amandine Pisoni 5, Esperance Nyiramigisha 6, Lise Montagnier 6, Karine Bollore 1, Ségolène Debiesse 1, David Morquin 2, Penelope Bourgoin 4, Nicolas Veyrenche 5, Constance Renault 1, Vincent Foulongne 5, Caroline Bret 7, Arnaud Bourdin, Vincent Le Moing 2, Philippe Van de Perre 5, Edouard Tuaillon 5,✉
PMCID: PMC7717347  PMID: 33206973

Abstract

We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (mCD169) in 53 adult patients admitted to the hospital during the COVID-19 outbreak for a suspicion of SARS-CoV-2 infection. mCD169 was strongly overexpressed in 30 out of 32 (93.7%) confirmed COVID-19 cases, compared to three out of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. mCD169 was associated with the plasma interferon alpha level and thrombocytopenia. mCD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.

Keywords: SARS-CoV-2, Covid-19, CD169, Monocytes, viral infections

Articles from The Journal of Infectious Diseases are provided here courtesy of Oxford University Press

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