Table 3:

Bivariate and multivariate association of progression-free survival with demographic and clinical characteristics in sample of patients with advanced or metastatic NSCLC (N=257)

			Bivariate model			Multivariate model
Covariate	Level	N	Hazard Ratio (95% CI)	HR P-value	Log-rank P-value	Hazard Ratio (95% CI)	HR P-value	Log-rank P-value
Race	Black/African American	75	1.17 (0.84–1.64)	0.357	0.386	2.70 (1.08–6.74)	0.033	0.077
	Other	18	0.76 (0.40–1.45)	0.402		0.66 (0.14–3.15)	0.604
	White/Caucasian	161	-	-		-	-
Sex	Female	130	0.82 (0.60–1.10)	0.188	0.184	0.34 (0.16–0.75)	0.007	0.007
	Male	127	-	-		-	-
ECOG	0	18	0.08 (0.01–0.68)	0.02	0.098	0.07 (0.01–0.83)	0.035	0.022
	1	84	0.13 (0.02–0.97)	0.047		0.05 (0.00–0.53)	0.013
	2	68	0.12 (0.02–0.94)	0.043		0.04 (0.00–0.45)	0.009
	3	21	0.13 (0.02–1.04)	0.055		0.15 (0.01–1.84)	0.14
	4	1	-	-		-	-
Income	Low/Middle Income	90	1.07 (0.77–1.48)	0.682	0.679	-	-	-
	High Income	142	-	-		-	-
Insurance	Government Insurance	165	0.89 (0.63–1.27)	0.528	0.525	0.45 (0.19–1.07)	0.071	0.071
	Private	67	-	-		-	-
Histology (NSCLC)	Non-Squamous NSCLC	190	0.77 (0.52–1.15)	0.207	0.203	-	-	-
	Squamous NSCLC	45	-	-		-	-
PD-L1 Status	<1%	29	2.25 (1.25–4.05)	0.007	0.02	5.38 (2.30–12.59)	<.001	<.001
	1–49%	20	1.61 (0.80–3.27)	0.183		2.26 (0.86–5.93)	0.098
	>=50%	47	-	-		-	-
BMI	Underweight/Normal Weight	132	0.95 (0.62–1.45)	0.805	0.34	-	-	-
	Overweight	73	1.22 (0.77–1.94)	0.39		-	-
	Obese	46	-	-		-	-
Brain metastasis	No	154	1.09 (0.78–1.51)	0.625	0.622	-	-	-
	Yes	86	-	-		-	-
Liver metastasis	No	192	0.56 (0.37–0.84)	0.005	0.004	-	-	-
	Yes	39	-	-		-	-
NLR	<5	122	0.92 (0.67–1.25)	0.583	0.582	0.31 (0.14–0.69)	0.004	0.004
	>=5	114	-	-		-	-
Age		257	1.00 (0.98–1.02)	0.793	-	-	-	-

^*Number of observations in the original data set = 257. Number of observations used = 62;

^**Backward selection with an alpha level of removal of 0.2 was used.

The following variables were removed from the model: Age, Brain Metastasis, Liver Metastasis, BMI, Histology (NSCLC), and Income