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. 2020 Dec 7;24(1):101903. doi: 10.1016/j.isci.2020.101903

Figure 1.

Figure 1

The structure of SARS-CoV-2 Nsp113-127

(A) Schematic of Orf1ab from SARS-CoV-2. The gray shading encompasses the non-structural proteins produced by Orf1a. Note, nsp11 is not produced by Orf1ab due to ribosomal frameshift (Naqvi et al., 2020). (B) Topological arrangement of SARS-CoV-2 Nsp113-127.

(C) Cartoon representation of the SARS-CoV-2 Nsp113-127 structure colored from N-terminus (blue) to C-terminus (red). Secondary structure elements and the N- and C-termini are labeled.

(D) Ribbon depiction of the structure, with side chains that contribute to the hydrophobic core of the beta-barrel shown in stick representation. The three layers of side chains (shown in red, blue, and green), plus the charged residues (shown in pink) at the bottom are colored and the residues within the layers are labeled.

(E) Electrostatic surface potential of the likely RNA-binding interface of SARS-CoV-2 Nsp113-127. R124 which is critical for the interaction with SL1 of the 5′UTR is labeled.