Figure 9:
Passive transfer of Qβ-glycan 1 immune rabbit sera protects mice against lethal S. Paratyphi A challenge. Pools of rabbit pre- and post-immunization sera were heat-inactivated and diluted 1:10 in PBS. These sera were then administered via the i.p. route to BALB/c mice (n=18/group). PBS was used as a negative control (n=10). Mice were challenged i.p. 6 hours later with 7.3 × 103 CFU of S. Paratyphi A strain ATCC 9150 in 10% HGM. A separate group of mice (n=5) was pre-treated with PBS followed by 10% HGM without S. Paratyphi A. Statistical significance was determined by a 2-tailed Fisher’s exact test, and comparisons between groups are indicated with brackets. P-values of <0.05 were considered statistically significant. **** p < 0.0001; ns: non-significant.