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Current knowledge of local gene regulation in radial glial cells (RGCs). Basal endfeet function far from the cell body embedded in a local niche comprised of basement membrane, fibroblasts and blood vessels. Three major discoveries in RGCs have been published: (a) mRNAs are actively transported from the cell body to basal endfeet. (b) Endfeet have a unique local transcriptome. (c) Endfoot localized mRNAs are competent for local translation
