. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: Neurotoxicology. 2019 Dec 19;77:40–50. doi: 10.1016/j.neuro.2019.12.012

Table 3.

Splenic monoamines and their metabolites in male C57BL6/J mice 6 h post chemicals exposure in two models of Gulf War Illness.

Monoamine or metabolite	Model 1				Model 2
Monoamine or metabolite	Vehicle – Vehicle	Vehicle – LNFPIII	PB/PM – Vehicle	PB/PM – LNFPIII	Vehicle – Vehicle	Vehicle – LNFPIII	PB/DEET/CORT/DFP – Vehicle	PB/DEET/CORT/DFP-LNFPIII
5-HT	80.29 ± 7.02	94.69 ± 4.46 ^b	96.99 ± 6.78 ^b	81.30 ± 6.60	80.29 ± 9.30	69.29 ± 5.78	107.44 ± 9.30 ^a	100.87 ± 14.27 ^a
5-HIAA	0.66 ± 0.04	0.71 ± 0.13	0.74 ± 0.09	0.66 ± 0.06	0.66 ± 0.12	0.71 ± 0.09	1.02 ± 0.22 ^a	1.42 ± 0.25 ^a
NE	66.83 ± 8.12	70.10 ± 12.17	59.16 ± 5.43	62.21 ± 8.90	95.83 ± 6.65	93.08 ± 9.90	90.84 ± 3.67	110.32 ± 11.65
MHPG	43.21 ± 1.98	48.77 ± 3.10	41.90 ± 1.80	47.55 ± 5.96	34.96 ± 2.58	39.45 ± 4.81	43.15 ± 3.79 ^a	51.82 ± 3.24^a

Data are presented as mean ± SEM; unit: ng/mg protein; n=6 per group, except the PB/DEET/CORT/DFP-Vehicle group, which was n=8).

^a and ^b indicate significant main effect for PB/DEET/CORT/DFP or Treatment (PB/PM x LNFPIII) interaction, respectively, after a two-way ANOVA (p ≤ 0.05) and are bolded.

Italicized values indicate trend (p < 0.10) for main effect of LNFPIII. Abbreviations: 5-HT: serotonin; 5-HIAA: 5-hydroxyindoleacetic acid; MHPG: 3-methoxy-4-hydroxyphenylglycol; NE: norepinephrine; PB: pyridostigmine bromide; PM: Permethrin; DEET: N,N-Diethyl-methylbenzamide; DFP: diisopropylfluorophosphate; CORT: corticosterone; LNFPIII: lacto-N-fucopentaose III.