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. 2020 Nov 25;9:e54497. doi: 10.7554/eLife.54497

Figure 1. Experimental setup.

(A) Diagram depicting the primary motor cortex hand knob in coronal section, with the ultrasound transducer coupled to the scalp via compressible hydrogel and held to the underside of a transcranial magnetic stimulation (TMS) coil with a 3D printed plastic holder (not to scale). The transducer and holder measure 10 mm thick, allowing for adequate magnetic stimulation of cortical neuron populations. (B) Photograph of the custom TUS-TMS delivery apparatus components, showing: (i) the active face of the TUS transducer, (ii) plastic 3D-printed holder, and (iii) 70 mm figure-eight TMS coil. The yellow dashed line indicates the recessed cutout for the hydrogel coupling pad.

Figure 1.

Figure 1—figure supplement 1. Material specifications for the 500 kHz 2-element annular ultrasound transducer, and scale photographs of coupling to TMS coil.

Figure 1—figure supplement 1.

Transducer manufacturer: Sonic concepts, Custom-made (Model H-246). Transducer Housing: Brass, RF-shielded, MRI-safe, water-tight. Cylindrical Housing dimensions: 38.1 mm outer diameter, 10 mm high. BNC Cable: 50 Ohms, side exit, 6-m length, exits housing on side. Center Frequency: (Fundamental): 500 kHz. Operating band: 400–600 kHz. Environment: MRI-safe, Immersible in water to a depth of 3.5 m, Matching Network: A fundamental resonance mode RF impedance matching network is supplied inside an RF-shielded external enclosure, intended for use with a 50 Ohm RF amplifier.