Figure 2.

H₂S signalling regulates macrophage functionality for the initiation and resolution of an inflammatory response. Upon stimulation (e.g. LPS and oxLDL), H₂S production is shut down at the early stage to facilitate pro‐inflammatory cytokine secretion, while at the late stage, the H₂S content becomes increased for induction of those mission‐completed macrophages to undergo apoptosis. Alerted H₂S signalling would lead to the development of immune or metabolic disorders. LPS, lipopolysaccharide; oxLDL, oxidized low‐density lipoprotein.