Reports from various parts of the world show that significant proportion of people who recovered from COVID-19 suffers from various health issues which are collectively called “long COVID-19” or post COVID-19 syndrome. The common symptoms include fatigue, breathlessness, cough, joint pain, chest pain, muscle aches, headaches and so on. Even though collectively called long COVID-19, researchers identified that it is a collection of at least 4 distinct clinical entities which are post-intensive care syndrome, post-viral fatigue syndrome, permanent organ damage, and long-term COVID-19 syndrome [1]. In our experience in addition to these we identified that drug related side effects, complications of COVID-19 (like pneumothorax, pneumomediastinum, vascular thrombosis leading to pulmonary thromboembolism, myocardial infarction, stroke etc), post-COVID-19 psychological issues and other infections (bacterial, other viral, fungal or re-infection with SARS-CoV-2 itself) can also cause similar symptoms in COVID-19 recovered patients. Careful evaluation to rule out causes unrelated to COVID-19 is important to offer correct treatment.
In people infected with SARS-CoV-2, 80% of infections are mild or asymptomatic, 15% are severe infection and 5% are critical infections [2]. Usually in people with mild disease symptoms resolve within 2 weeks, where as in severe illness it may persist for 3–6 weeks [3]. Presence of long COVID-19 challenges the assumption that “mild” disease recover within 2 weeks [4].
There are lots of challenges in the diagnosis of long COVID-19. Those who had history of typical symptoms of acute COVID-19 with positive throat swab RT-PCR, presenting with long duration symptoms, the diagnosis of long COVID is straight forward. But those with acute COVID-19 symptoms and negative throat swab RT-PCR, presenting with long symptoms pose real challenge in day to day clinical practice. Significant proportions of SARS-CoV-2 infected individuals are asymptomatic. And development of long COVID-19 symptoms in those asymptomatic individuals adds to the diagnostic confusion. Similarly the duration of acute symptoms vary in patients again adding confusion to differentiate acute COVID-19 from long COVID-19. Based on our experience and after reviewing relevant literature, we are proposing criteria for the diagnosis of long COVID-19 (Table 1 ).
Table 1.
Proposed Diagnostic criteria for Long COVID-19 |
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A. ESSENTIAL CRITERIA (Evidence of preceding infection with SARS-CoV-2 within last 2–4 weeks) |
Symptomatic |
Confirmed |
Clinical features consistent with COVID-19, with positive throat swab RT-PCR |
Clinical features consistent with COVID-19, with negative throat swab RT- PCR, with positive antibody testing |
Probable |
Clinical features consistent with COVID-19, with negative throat swab RT-PCR and antibody testing, with CT thorax or chest X ray consistent with COVID-19 in presence of contact with confirmed or suspected case of COVID-19 within 2 weeks of onset of symptoms |
Clinical features consistent with COVID-19, with negative throat swab RT-PCR, antibody testing and negative CT thorax and chest X ray in presence of contact with confirmed or suspected case of COVID-19 within 2 weeks of onset of symptoms |
Possible |
Clinical features consistent with COVID-19, with negative throat swab RT-PCR and antibody testing, with CT thorax or chest X ray consistent with COVID-19 in the absence of contact with confirmed or suspected case of COVID-19 within 2 weeks of onset of symptoms, in the setting of community transmission |
Clinical features consistent with COVID-19, with negative throat swab RT-PCR, antibody testing and negative CT thorax and chest X ray in the absence of contact with confirmed or suspected case of COVID-19 within 2 weeks of onset of symptoms, in the setting of community transmission |
Doubtful |
Clinical features consistent with COVID-19, with negative throat swab RT-PCR, antibody testing and negative CT thorax and chest X ray in the absence of contact with confirmed or suspected case of COVID-19 within 2 weeks of onset of symptoms in the absence of community transmission |
Asymptomatic |
Confirmed |
Either positive throat swab RT-PCR or positive antibody testing or both |
Probable |
Negative throat swab RT-PCR and antibody testing with CT thorax, chest X ray consistent with COVID-19 in presence of contact with confirmed or suspected case of COVID-19 |
Possible |
Negative throat swab RT-PCR, antibody testing and negative CT thorax and chest X ray in presence of contact with confirmed or suspected case of COVID-19 |
Doubtful |
Negative throat swab RT-PCR, antibody testing and negative CT thorax and chest X ray in the absence of contact with confirmed or suspected case of COVID-19 in the setting of community transmission |
B.CLINICAL CRITERIA Symptoms of Long COVID-19 |
Presence of symptoms (new or persistent) like fatigue, breathlessness, cough, joint pain, chest pain, muscle aches, headache and so on which could not be attributed to any other cause |
C.DURATION CRITERIA Duration |
In SARS-CoV-2 infected symptomatic individuals, presence of symptoms |
More than 2 weeks in mild disease More than 4 weeks in moderate/severe illness More than 6 weeks in critical illness |
In SARS-CoV-2 infected asymptomatic individuals, presence of symptoms |
Appearance of symptoms after 2 weeks of RT-PCR positivity Appearance of symptoms after 1 weeks of antibody positivity Appearance of symptoms after 2 weeks of positive CT thorax or chest X ray Appearance of symptoms after 2 weeks after contact with suspected or positive case of COVID-19 Anytime in doubtful cases |
(Note: Those who did not undergo throat swab RT-PCR or antibody testing also considered as test negative).
Clinical criteria (symptoms of Long COVID-19) after defined time period in presence of essential criteria (evidence of preceding SARS-CoV-2 infection) helps to categorise long COVID-19 as confirmed, probable, possible or doubtful long COVID-19 syndrome (Table 2 ).
Table 2.
Clinical category | Clinical features | Throat swab RT-PCR | SARS-CoV-2 antibody | Chest X ray/CT thorax | History of contact with confirmed/suspected case of COVID-19 | Community spread | Clinical status of previous SARS-CoV-2 infection | Long COVID-19 symptom duration |
---|---|---|---|---|---|---|---|---|
Symptomatic | + | + | ± | ± | ± | ± | Confirmed | More than 2 weeks in mild disease More than 4 weeks in moderate/severe illness More than 6 weeks in critical illness |
+ | - | + | ± | ± | ± | |||
+ | - | - | + | + | ± | Probable | ||
+ | - | - | - | + | ± | |||
+ | - | - | + | - | + | Possible | ||
+ | - | - | - | - | + | |||
+ | - | - | - | - | - | Doubtful | ||
Asymptomatic | - | + | ± | ± | ± | ± | Confirmed | Appearance of symptoms after 2 weeks of positive RT-PCR or 1 week of positive antibody testing |
- | - | + | ± | ± | ± | |||
- | - | - | + | + | ± | Probable | Appearance of symptoms after 2 weeks of positive result or contact | |
- | - | - | - | + | ± | Possible | Appearance of symptoms after 2 weeks of contact with positive case | |
- | - | - | - | - | + | Doubtful | Anytime |
References
- 1.NIHR . 2020. Living with covid-19. A dynamic review of the evidence around ongoing covid-19 symptoms (often called long covid)https://evidence.nihr.ac.uk/themedreview/living-with-covid19 [Google Scholar]
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