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SIRT1 inhibitor, selisistat reversed the anti-oxidative stress and anti-apoptotic effects of MC1R at 24 h after SAH. (A) Representative western blot images; (B) Quantitative analyses of MC1R, p-AMPK, SIRT1, PGC-1α, UCP2, GPx, SOD, CC-3, Bcl-2, Bax. Data were shown as means ± SD and compared by 1-way ANOVA followed by the Tukey post-hoc test. *p < 0.05 vs. sham, &p < 0.05 vs. SAH + vehicle, #p < 0.05 vs. SAH + BMS-470539.
