Table 2.
List of cancer related 3D printed microfluidic chip during the past five years
| Research contents | 3D printing method | Function of 3D printing | Notes | Ref. |
|---|---|---|---|---|
| Compared with the suitability of SLA and PloyJet method in printing microstructure of microfluidic device. | SLA and PolyJet bioprinting | Printed microstructure of microfluidic device | 3D tumor spheroid; Liver cancer | 178 |
| Constructed a 3D microfluidic model to conduct the pharmacodynamic tests of an anti-CD147 monoclonal antibody. | Integrated printing | 3D cell printing | 3D culture; Liver cancer | 39 |
| Constructed a metastasis model on chip to investigate bone metastasis in breast cancer. | - | Fabricated the cast molds | 3D culture; Breast cancer | 26 |
| Breast cancer cell morphology, migration, and the interaction with bone matrix on chip. | SLA | Constructed a 3D biomimetic bone matrix | 3D culture; Breast cancer | 179 |
| Explored the effect of variable peptide-engineered exosomes in cancer immunotherapy. | - | Fabricated microfluidic culture chip | The yield and purity of engineered exosomes were improved, and the operation time was reduced. | 180 |
| A low-cost with ultralow detection limit immunoarray was developed to analyze the expression of multiple biomarker proteins in serum samples from cancer patients. | SLA | Fabricated microfluidic chip | Detected prostate cancer biomarker proteins in serum; Low sample volume. | 181 |
| Developed a “Lab-on-a-printer” and demonstrated its function by printed type Ⅰ collagen seeded with liver cancer cells. | Inkjet bioprinting | Fabricated chip and formed patterned biological structure by printing bio-ink | This platform integrated microfluidic mixer with inkjet dispenser on a chip. | 182 |