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. 2020 Nov 27;10(12):1607. doi: 10.3390/biom10121607

Figure 2.

Figure 2

Dermal-epidermal junction components, receptors, and intermolecular binding. The epidermal basement membrane contains laminins, nidogens, collagens IV, VII, XVII, and XVIII, perlecan, and fibulins. Majors receptors and other cell surface binding molecules include integrins and dystroglycan. Collagen IV and laminins 511/521 form networks connected to one another by nidogens and perlecan. Other interacting partners and protein domains involved in molecular interactions are indicated. A focus on the extracellular matrix components of anchoring complexes and their interactions are presented in the central dotted frame. Laminin-332 and -311, collagen VII and XVII, and α6β4 integrin are shown. Laminins of the dermal-epidermal junction interact with keratinocytes receptors through the C-terminal laminin globular (LG) domains of their α chain. Non-collagenous (NC); globule (G), sedimentation coefficient 7S (7S), domain (D), N-terminal domain (N); β sub-unit of dystroglycan (β-DG); α sub-unit of dystroglycan (α-DG).