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. 2020 Dec 4;12(12):1181. doi: 10.3390/pharmaceutics12121181

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) AA of quercetin and ascorbic acid (positive controls), free extract, extract-loaded PLGA NPs, extract-loaded PCL NPs, (%, mean ± S.D.; n = 3, *** p < 0.001, when compared the quercetin with the other samples, ⁺⁺⁺ p < 0.001, when compared the ascorbic acid with the other samples, ^### p < 0.001, when compared the free extract with the other samples and ^∆∆∆ p < 0.001, when compared the rutin with the other samples), (b) Difference of AA in release medium when compared with respective extract-loaded NPs (%, mean ± S.D.; n = 3).