Table 7.

The list of 55 core targets ranked by degree value.

NO	Gene Name	Protein Name	Degree	NO	Gene Name	Protein Name	Degree
1	AKT1	RAC-alpha serine/threonine-protein kinase	42	29	MMP3	Stromelysin-1	14
2	VEGFA	Vascular endothelial growth factor A	41	30	NOX4	NADPH oxidase 4	14
3	MAPK3	Mitogen-activated protein kinase 3	37	31	PPARA	Peroxisome proliferator-activated receptor alpha	13
4	PTGS2	Prostaglandin G/H synthase 2	34	32	HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase	13
5	ESR1	Estrogen receptor	33	33	INSR	Insulin receptor	12
6	MAPK1	Mitogen-activated protein kinase 1	33	34	MMP13	Collagenase 3	12
7	CASP3	Caspase-3	33	35	GSTP1	Glutathione S transferase P	12
8	SRC	Proto-oncogene tyrosine-protein kinase Src	30	36	LDLR	Low-density lipoprotein receptor	11
9	MMP2	72 kDa type IV collagenase	28	37	KIT	Mast/stem cell growth factor receptor Kit	11
10	CAT	Catalase	24	38	CYP1B1	Cytochrome P450 1B1	11
11	SERPINE1	Plasminogen activator inhibitor 1	24	39	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	10
12	APP	Amyloid-beta precursor protein	24	40	CYP2C9	Cytochrome P450 2C9	10
13	KDR	Vascular endothelial growth factor receptor 2	22	41	F3	Tissue factor	10
14	ADIPOQ	Adiponectin	22	42	GSR	Glutathione reductase, mitochondrial	9
15	PPARG	Peroxisome proliferator-activated receptor gamma	22	43	FGFR1	Fibroblast growth factor receptor 1	9
16	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	21	44	SHBG	Sex hormone-binding globulin	9
17	BCL2L1	Bcl-2-like protein 1	21	45	BCL2	Apoptosis regulator Bcl-2	8
18	IGF1R	Insulin-like growth factor 1 receptor	20	46	UGT1A1	UDP-glucuronosyltransferase 1A1	8
19	SOD1	Superoxide dismutase	18	47	EDNRA	Endothelin-1 receptor	7
20	APOB	Apolipoprotein B-100	18	48	PLA2G2A	Phospholipase A2	7
21	CYP3A4	Cytochrome P450 3A4	18	49	CTSL	Procathepsin L	7
22	IGFBP3	Insulin-like growth factor-binding protein 3	18	50	SYK	Tyrosine-protein kinase SYK	6
23	CYP19A1	Aromatase	18	51	VCP	Transitional endoplasmic reticulum ATPase	6
24	ABCG2	Broad substrate specificity ATP-binding cassette transporter ABCG2	17	52	PTGS1	Prostaglandin G/H synthase 1	6
25	RELA	Transcription factor p65	16	53	ADORA1	Adenosine receptor A1	5
26	HNF4A	Hepatocyte nuclear factor 4-alpha	16	54	BCHE	Cholinesterase	5
27	MET	Hepatocyte growth factor receptor	15	55	MMP12	Macrophage metalloelastase	2
28	ESR2	Estrogen receptor beta	14