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. 2020 Dec 12;8(12):598. doi: 10.3390/biomedicines8120598

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Soluble uric acid attenuates IL-1β release from infected macrophages. (A) Murine RAW264.7 macrophages infected with formalin-fixed bacteria in presence and absence of soluble uric acid (19 mg/dL) and incubated overnight. IL-1β release in the supernatants was quantitated using ELISA method. These data represent the mean of six independent experiments with bars showing the standard error of the mean. (B) IL-1β released from human THP-1 monocytic cells induced similar to panel A above. KPS: K. pneumoniae sensitive to antibiotics; KPR: K. pneumoniae resistant to antibiotics; SA: S. aureus; MRSA LR: methicillin-resistant S. aureus with low level of resistance; MRSA HR: methicillin-resistant S. aureus with high level of resistance; UA: uric acid; ns: not significant. p value < 0.05 are significant; **** in comparison to KPS without uric acid.