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. 2020 Dec 10;25(24):5845. doi: 10.3390/molecules25245845

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pyranoxanthone 2 (PX2) treatment promotes death in mitosis, after prolonged arrest. (a) Mitosis duration as determined by time-lapse microscopy, in untreated (control) and PX2-treated cells. Each spot represents one cell. (b) Representative time-lapse sequences of untreated and PX2-treated cells. Untreated cell undertakes mitosis for about 30 min (top), while PX2-treated cell (bottom) arrests in mitosis during several hours (457.8 ± 264.2 min) followed by death. Numbers indicate times in 00 h:00 min. Movies are available as Supplementary materials. (c) Quantification of cell fate after PX2 treatment. The percentage of cells undergoing post-mitotic death (PMD) and death in mitosis (DIM), and cells with normal cycling, over the total number of cells are represented.