Figure 2.

Plasma miRNAs regulated in Heart Failure. Twelve circulating miRNAs showed increased levels in patients belonging to NYHA class I to IV vs. healthy controls (C), even after adjustment for age, sex, personal history of diabetes mellitus, hypertension, and/or hypercholesterolemia, and smoking habit. These miRNAs were all significant at the analysis of covariance (ANCOVA) for p < 0.01. The expression of each miRNA is represented by box and whiskers plots. C n = 10, NYHA I n = 14, NYHA II n = 17, NYHA III n = 16, NYHA IV n = 14. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 at Tukey’s multiple comparison test.