Figure 2.

Cancers in which specific connexin functions have been described to be tumor suppressive. Schematic showing examples of the cancer types in which tumor suppressive properties have been attributed to a specific connexin function, whether gap junction intercellular communication (GJIC), connexin hemichannels, or a non-junctional function. Bold blue text indicates strong evidence from many cancer types tying the connexin function to the corresponding cancer hallmark, with blue text indicating a less robust link and black text indicating emerging evidence. Where mechanistic studies in cancer cells are not available, certain non-transformed cell populations are indicated. References for the indicated cancers are provided in the text. Figure illustrations generated using BioRender.com.