Skip to main content
. 2020 Dec 13;12(12):1434. doi: 10.3390/v12121434

Figure 1.

Figure 1

Inhibition of viral shedding in response to (A) acyclovir (ACV) or (B) UL29 siRNA swarm. The fitted curves represent circulating clinical (solid lines, N = 17) or reference strains (dashed lines, N = 2) of HSV-1. In all antiviral assays, Vero cells were treated with the antiviral agent on 96-well plates, infected 4 h post treatment (hpt) with 100 plaque forming units (pfu) per well, and finally quantified for reduction of viral production into the culture medium at 72 hpt. The dose is shown as log (nM) for both antivirals. The response is shown as inhibition percentage (%) in comparison to untreated cells for ACV and to water-treated cells for the UL29 siRNA swarm. The ACV plaque reduction assay was conducted in duplicates, and the antiviral siRNA swarm assay with five or more biological replicates for each concentration.