Table 2.
Finnish clinical HSV-1 isolates and their sensitivities (IC50) to ACV or to UL29 siRNA treatment.
| HSV-1 Strain | Sample No. | IC50 ACV (nM) 1 | IC50, UL29 Swarm (nM) 1 |
|---|---|---|---|
| HSV-1 (17+) | - | 349.7 2 | 0.8 |
| HSV-1 (F) | - | 803.3 | 0.7 |
| HSV-1 (Δ305) | - | 25468.8 2 | 1.0 |
| F-14g | H12114 | 1425.8 2 | 1.4 |
| F-15 | H12115 | 488.2 | 1.0 |
| F-17 | H12117 | 995.0 2 | 2.5 |
| F-18g | H12118 | 526.1 2 | 1.1 |
| F-19 | H12119 | 921.1 | 1.1 |
| M-15 | H1215 | 784.9 2 | 2.3 |
| M-10 | H15110 | 1023.2 | 1.9 |
| F-12 | H15112 | 1016.1 | 0.9 |
| F-15g | H15115 | 895.1 | 1.1 |
| F-17/ | H15117 | 527.9 | 0.9 |
| M-19 | H15119 | 644.9 2 | 1.7 |
| M-17 | H1517 | 1911.2 | 3.0 |
| M-19/ | H1519 | 1079.8 | 0.5 |
| M-01 | H151V1 | 624.0 | 0.9 |
| M-02 | H151V2 | 559.3 | 0.9 |
| M-03 | H151V3 | 575.1 | 0.5 |
| M-04 | H151V4 | 349.7 | 1.0 |
| Average of circulating strains | 844.0 | 1.3 | |
| Standard deviation of circulating strains | 379.1 | 0.7 | |
1 The IC50 values were determined in Vero cells and are expressed as nM values. The infection was done 4 h post treatment, using 100 plaque forming units/well of each virus. 2 ACV sensitivity of the strain according to Bowen et al., 2019 [9].