Table 1.
Top 20 drugs and their toxicities, ranked by GI.
| Substance | Rank (GI) | Tox@GI | Rank (PoD) | Tox@PoD | Rank (AUC) |
|---|---|---|---|---|---|
| Itraconazole | 1 | 0.000 | 64 | inf | 10 |
| Bortezomib | 2 | 0.411 | 63 | inf | 1 |
| Actinomycin D | 3 | 0.596 | 1 | 0.636 | 6 |
| Dinaciclib | 4 | 0.586 | 2 | 0.641 | 8 |
| Staurosporine | 5 | 0.472 | 4 | 0.654 | 2 |
| Ganetespib | 6 | 0.566 | 3 | 0.600 | 3 |
| Romidepsin | 7 | 0.000 | 12 | 0.005 | 7 |
| MLN9708 | 8 | inf | 5 | inf | 4 |
| Carfilzomib | 9 | 0.930 | 6 | 0.930 | 5 |
| Homoharringtonine | 10 | 0.659 | 7 | 0.696 | 9 |
| PF-04691502 | 11 | 0.345 | 8 | 0.329 | 14 |
| BAY80-6946 | 12 | inf | 9 | inf | 13 |
| INK128 | 13 | inf | 28 | inf | 12 |
| Obatoclax | 14 | 0.534 | 10 | 0.434 | 11 |
| Panobinostat | 15 | 0.658 | 11 | 0.639 | 16 |
| Auranofin | 16 | inf | 13 | inf | 15 |
| 17-AAG | 17 | inf | 14 | inf | 17 |
| Idarubicin hydrochloride | 18 | 0.834 | 16 | 0.790 | 19 |
| Fludarabine phosphate | 19 | 0.000 | 22 | 0.000 | 24 |
| Daunorubicin hydrochloride | 20 | 0.710 | 17 | 0.675 | 20 |