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. 2020 Dec 19;12(12):1468. doi: 10.3390/v12121468

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Alignment of the deduced amino acid sequences of the VP1/P2B junction of the HM175 strain and 13 out of the 47 hepatitis A virus (HAV) strains carrying the C70S and/or M104I changes. Conserved sites, substitutions and deletions are represented by dots, single-letter abbreviation and the letter “X”, respectively. The red arrows and blocks highlight amino acid change at position 70 and 104, and their surroundings. The black arrows point to HAV genotype II reference strains that carry the C70S change. The blue arrows point to HAV genotype III reference strains that carry the M104I change. The protein alignment containing all 47 HAV strains is provided as Supplementary files 6 (graphic view) and 7 (Fasta file).