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. 2020 Dec 17;7(6):ENEURO.0235-20.2020. doi: 10.1523/ENEURO.0235-20.2020

Figure 3.

Figure 3.

Captopril and losartan increase retinal GFP in flies expressing AD London Mutation, C99V717I. Confocal GFP and light microscope images of 7-d gmr-GAL4-UAS-GFP>UAS-C99wt, gmr-GAL4-UAS-GFP>UAS-C99V717I, and gmr-GAL4-UAS-GFP>UAS-Aβ42 fly heads shown as labeled with or without drug treatments (top panel). One-way ANOVA of GFP quantification in gmr>C99wt flies showed no significant differences when administered either drug (N = 49 for captopril; N = 34 for losartan, p = 0.2374). Similar results were found for gmr>Aβ42 flies (N = 25 for captopril; N = 28 for losartan, p = 0.182). However, one-way ANOVA of GFP quantification in gmr>C99V717I flies showed a significant effect of drug condition (p = 0.0006). Post hoc analysis using Bonferroni’s multiple comparison test showed that both captopril (N = 51) and losartan (N = 61) significantly increased retinal GFP (p = 0.0363, p = 0.0003, respectively). Data are shown as mean ± SEM; *p < 0.05, ***p < 0.001; n.s., not significant.