Figure 2.
Atypical social interactions in Flr mice. A, Three-chamber social approach test where a caged NM in chamber 3 (C3) and a NO in chamber 1 (C1) were placed (n = 17 for both WTFLR and Flr). B, Percentage of time spent interacting with NM (sniffing and close proximity to the NM cage; Movies 3, 4). C, Social proximity test with Flr-Flr and WTFLR-WTFLR pairs. The behaviors measured were nose tip-to-nose tip sniffing (with/without contact; NN), NH sniffing, NA sniffing (n = 20 for both WTFLR and Flr). D, Social proximity test with Flr-WTFLR pairs Flr to quantify avoiding/pushing and grooming behaviors (Movies 5, 6). Unpaired t test and sum-rank test was used for statistical analysis; *p ≤ 0.05, **p ≤ 0.001, ***p ≤ 0.0001. Error bars represent ±SEM.