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. 2020 Dec 15;7(6):ENEURO.0284-20.2020. doi: 10.1523/ENEURO.0284-20.2020

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Copyright © 2020 Pandian et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Synaptic transport of proteins to PSD is altered in Flr mice. WT_FLR and Flr hippocampal synaptosome extracts were used for quantitative Western blot analyses of synaptic proteins. A1, A2, Levels of full-length MyoVa and TLS/FUS were reduced in Flr extracts. B1, B2, Expression levels of major MAGUKs (PSD-95, PSD-93, SAP102) and (C1, C2) SAPAP1, SHANK1, SHANK3, Homer1b/c, and IP3R were significantly reduced in Flr. D1, D2, mGluRs, NMDAR, AMPAR subunit levels, and FMRP were not changed in Flr when compared with WT_FLR. Homogenate (Homo) and synaptosome (Syn) was prepared from whole hippocampus. Protein levels in Flr were quantified and plotted as % of WT_FLR; n = 3 samples per group/each sample pool three to five animals. Unpaired t test was used for statistical analysis. Error bars represent ±SEM; *p ≤ 0.05, **p ≤ 0.001.