Figure 5.

The Influence of Locomotion on V_m Differs Depending on Mismatch Response

(A) Example V_m trace (black) from a neuron during locomotion onset (vertical dashed line) in the open-loop condition. Dotted lines indicate 0 cm/s.

(B) Average V_m response to locomotion onset (purple dashed line) for the example neuron in (A). Shading indicates SEM over 4 trials. The value in gray bold italics indicates the mean pre-locomotion voltage.

(C) Top: heatmap of average V_m responses to locomotion onset for all L2/3 neurons. Responses are sorted as in Figure 2A. Gray shading marks neurons for which we did not have sufficient data. Bottom: average locomotion onset response across 10 dMM neurons (orange), 4 hMM neurons (turquoise), and 8 unclassified neurons (gray). Shading indicates SEM over neurons.

(D) Scatterplot between locomotion onset response and mismatch response for 22 neurons. Boxplots compare responses for 4 hMM neurons (turquoise), 10 dMM neurons (orange), and 8 unclassified neurons (gray). One-way ANOVA, p = 0.43, F-statistic = 0.9.

(E) As in (D), but for correlation coefficients between locomotion speed and V_m (when excluding stationary periods). Boxplots above compare values for 12 dMM (orange), 5 hMM (turquoise), and 5 unclassified neurons (gray). One-way ANOVA, p < 0.02, F-statistic = 5.8; dMM versus hMM: p < 0.005, dMM versus unclassified: p = 0.37, hMM versus unclassified: p < 0.05, t test.

(F) Average cross-correlations between V_m and locomotion speed (black) or visual flow speed (gray). Negative time values indicate locomotion/visual speed preceding V_m. Shading indicates SEM over neurons.