1715. Influenza-like Illness (ILI) Experience Among Healthcare Workers in Military Treatment Facilities: An Offshoot of the Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD (PAIVED) Study

Rhonda Colombo; Stephanie Richard; Christina Schofield; Limone Collins; Anuradha Ganesan; Casey Geaney; David Hrncir; Tahaniyat Lalani; Ana E Markelz; Ryan C Maves; Bruce McClenathan; Katrin Mende; Jitendrakumar Modi; Jay R Montgomery; Srihari Seshadri; Catherine Skerrett; Christina Spooner; Gregory Utz; Tyler Warkentien; Timothy Burgess; Timothy Burgess; Christian L Coles

doi:10.1093/ofid/ofaa439.1893

. 2020 Dec 31;7(Suppl 1):S841. doi: 10.1093/ofid/ofaa439.1893

1715. Influenza-like Illness (ILI) Experience Among Healthcare Workers in Military Treatment Facilities: An Offshoot of the Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD (PAIVED) Study

Rhonda Colombo ¹, Stephanie Richard ², Christina Schofield ³, Limone Collins ⁴, Anuradha Ganesan ⁵, Casey Geaney ⁶, David Hrncir ⁷, Tahaniyat Lalani ⁸, Ana E Markelz ⁹, Ryan C Maves ¹⁰, Bruce McClenathan ¹¹, Katrin Mende ¹², Jitendrakumar Modi ¹³, Jay R Montgomery ¹⁴, Srihari Seshadri ¹⁵, Catherine Skerrett ¹⁶, Christina Spooner ¹⁵, Gregory Utz ¹⁷, Tyler Warkentien ¹⁸, Timothy Burgess ¹⁹, Timothy Burgess ¹⁹, Christian L Coles ²⁰

¹ Madigan Army Medical Center, Tacoma, WA, Infectious Disease Clinical Research Program, Bethesda, MD, and Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, Tacoma, Washington

² Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD and Henry M. Jackson Foundation, Bethesda, MD, Bethesda, MD

³ Madigan Army Medical Center, Tacoma, WA, Tacoma, Washington

⁴ Immunization Health Branch, Defense Health Agency Bethesda, MD, Falls Church, VA, San Diego, CA, Falls Church, VA

⁵ Infectious Disease Clinical Research Program and the Henry M. Jackson Foundation for the Advancement of Military Medicine and Walter Reed National Military Medical Center, Bethesda, Maryland

⁶ Walter Reed National Military Medical Center, Bethesda, MD

⁷ Lackland Air Force Base & Carl R. Darnall Army Medical Center, San Antonio, Texas

⁸ Infectious Disease Clinical Research Program, Bethesda, MD, The Henry M. Jackson Foundation, Bethesda, MD, and Naval Medical Center Portsmouth, VA, Portsmouth, Virginia

⁹ Brooke Army Medical Center, Fort Sam Houston, Texas

¹⁰ Naval Medical Center San Diego, San Diego, CA and Infectious Disease Clinical Research Program, Bethesda, MD, San DIego, California

¹¹ Womack Army Medical Center, Fort Bragg, NC 28310, Fort Bragg, North Carolina

¹² Infectious Disease Clinical Research Program, Bethesda, MD, The Henry M. Jackson Foundation, Bethesda, MD, and Brooke Army Medical Center, Fort Sam Houston, TX, San Antonio, TX

¹³ NHC Annapolis, Laurel, Maryland

¹⁴ Defense Health Agency, Vienna, Virginia

¹⁵ Immunization Health Branch, Defense Health Agency, Falls Church, VA

¹⁶ Lackland Air Force Base, San Antonio, Texas

¹⁷ Naval Medical Center San Diego, Infectious Disease Clinical Research Program, Bethesda, MD, and Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, San Diego, California

¹⁸ Naval Medical Center Portsmouth, Portsmouth, VA, Portsmouth, VA

¹⁹ Infectious Disease Clinical Research Program, Bethesda, MD, Bethesda, Maryland

²⁰ Infectious Disease Clinical Research Program, Bethesda, MD, The Henry M. Jackson Foundation, Bethesda, MD, Bethesda, MD

PMCID: PMC7777960

Abstract

Background

Healthcare workers (HCWs) are at heightened risk of exposure to respiratory pathogens. There are limited published data on influenza-like illness (ILI) experience among HCWs, and the few available studies were hampered by incomplete vaccination histories. PAIVED, a multicenter, multiservice study assessing influenza vaccine effectiveness in the Department of Defense, provides a unique opportunity to describe ILI experience among vaccinated HCWs compared to vaccinated non-HCWs.

Methods

PAIVED participants were randomized to receive either egg-based, cell-based, or recombinant-derived influenza vaccine then surveyed weekly for ILI. At enrollment, participants provided key demographic data including whether they were HCWs with direct patient contact. ILI was defined a priori as 1) having cough or sore throat plus 2) feeling feverish/having chills or having body aches/fatigue. Participants with ILI completed a daily symptom diary for seven days and submitted a nasal swab for pathogen detection.

Results

Of 4433 eligible participants enrolled during the 2019-20 influenza season, 1551 (35%) were HCWs. A higher percentage of HCWs experienced an ILI than non-HCWs (34% vs 26%, p< 0.001). Overall, HCWs were more likely to be female (42% vs 32%), age 25-34 years (39% vs 28%), active-duty military (81% vs 62%), non-smokers (88% vs 75%), and physically active (92% vs 85%). Self-reported race differed between HCWs and non-HCWs; a higher proportion of HCWs identified as White (63% vs 56%) or Asian (8% vs 5%). Similar demographic differences existed among HCWs and non-HCWs with ILI. HCWs were more likely to respond to at least 50% of weekly surveillance messages, irrespective of ILI status. HCWs with ILI had less severe lower respiratory symptoms (p< 0.001) and a shorter duration of illness (12.4±8.1 days vs 13.7±9.0, p=0.005) than non-HCWs. Pathogen data is pending.

Conclusion

HCWs in PAIVED were more likely to report ILI than their non-HCW counterparts yet tended to have lower illness severity, possibly reflecting a higher level of baseline health or enhanced awareness of early ILI symptoms. The important epidemiologic position HCWs occupy for ILI has been apparent in the COVID-19 pandemic. Exploring ways to mitigate ILI risk in HCWs beyond influenza vaccination is warranted.

Disclaimer

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Disclosures

All Authors: No reported disclosures

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1715. Influenza-like Illness (ILI) Experience Among Healthcare Workers in Military Treatment Facilities: An Offshoot of the Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD (PAIVED) Study

Rhonda Colombo, MD, MHS

Stephanie Richard, PhD, MHS

Christina Schofield, MD

Limone Collins, MD

Anuradha Ganesan, MBBS, MPH

Casey Geaney, MD

David Hrncir, MD

Tahaniyat Lalani, MBBS

Ana E Markelz, MD

Ryan C Maves, MD

Bruce McClenathan, MD, FACP,FAAAAI

Katrin Mende, PhD

Jitendrakumar Modi, MD

Jay R Montgomery, MD

Srihari Seshadri, MBBS, MPH

Catherine Skerrett, MSN, FNP, RN

Christina Spooner, MS

Gregory Utz, MD

Tyler Warkentien, MD, MPH

Timothy Burgess, MD, MPH

Timothy Burgess, MD, MPH

Christian L Coles, PhD

Abstract

Background

Methods

Results

Conclusion

Disclosures

ACTIONS

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Cite

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PERMALINK

1715. Influenza-like Illness (ILI) Experience Among Healthcare Workers in Military Treatment Facilities: An Offshoot of the Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD (PAIVED) Study

Rhonda Colombo, MD, MHS

Stephanie Richard, PhD, MHS

Christina Schofield, MD

Limone Collins, MD

Anuradha Ganesan, MBBS, MPH

Casey Geaney, MD

David Hrncir, MD

Tahaniyat Lalani, MBBS

Ana E Markelz, MD

Ryan C Maves, MD

Bruce McClenathan, MD, FACP,FAAAAI

Katrin Mende, PhD

Jitendrakumar Modi, MD

Jay R Montgomery, MD

Srihari Seshadri, MBBS, MPH

Catherine Skerrett, MSN, FNP, RN

Christina Spooner, MS

Gregory Utz, MD

Tyler Warkentien, MD, MPH

Timothy Burgess, MD, MPH

Timothy Burgess, MD, MPH

Christian L Coles, PhD

Abstract

Background

Methods

Results

Conclusion

Disclosures

ACTIONS

PERMALINK

RESOURCES

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