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[Preprint]. 2022 Nov 9:2020.12.20.423533. Originally published 2020 Dec 20. [Version 2] doi: 10.1101/2020.12.20.423533

Figure 3. ORF3a is expressed in the brain of COVID-19 patients.

Figure 3.

A. Diagram of the human brain. B. Summary of the histological findings shown in C. The cerebellum and hippocampus samples from COVID-19 patients (patients 2,3 and 6) showed distinct and specific SARS-CoV-2 ORF3a antibody staining. Positive staining was not observed in uninfected controls. C. Micrographs of FFPE sections from COVID-19 patients and uninfected patients stained with an ORF3a antibody. In the cerebellum, ORF3a protein (brown) was detected in the plasmalemma and cytolymph of Purkinje cells (patient 2, red arrowheads) and Granular cells (patient 3, red arrows). In the hippocampus ORF3a protein was detected in pyramidal cells in (patients 2 and 6, blue arrowheads).