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. 2020 Jul 14;45(13):2147–2154. doi: 10.1038/s41386-020-0769-x

Fig. 2. Association of suicidal ideation with irritability and overall depression in CO-MED, EMBARC, and SAMS trials.

Fig. 2

*Standardized β estimates (all symptom measures were standardized with mean of 0 and standard deviation of 1) were obtained from separate linear mixed models with Concise Health Risk Tracking (CHRT) scale suicidal thoughts factor as the dependent variable and irritability and overall depression as independent variables in Combining Medications to Enhance Depression Outcomes (CO-MED; n = 665, a), Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC; n = 296, b), and Suicide Assessment Methodology Study (SAMS; n = 266, c). Error bars represent 95% confidence interval of the standardized β estimates. Irritability was assessed with the five-item irritability domain of Concise Associated Symptom Tracking (CAST) scale. Suicidal ideation was assessed with three-item suicidal thoughts factor of Concise Health Risk Tracking (CHRT) scale. Overall depression was assessed with the Hamilton Depression Rating Scale in the EMBARC trial, and with Quick Inventory of Depressive Symptomatology Clinician-Rated version in the CO-MED and SAMS trials, after excluding the suicidality-related item.