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. 2020 Mar 3;35(1):47–61. doi: 10.1038/s41375-020-0762-8

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© The Author(s) 2020

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Fig. 6 — AML cases are primarily ordered according to the WHO 2016 classification and secondarily according to the proposed genetic AML classification [9]. Relevant variants with respect to the genetic classification and potentially actionable targets are indicated per case. Red font indicates parameters provided by HAMLET that cannot be reliably addressed by metaphase cytogenetics and targeted NGS sequencing. Prognosis according to the ELN risk [1] is indicated at the bottom. In addition, cases whose ELN risk was altered by HAMLET information are indicated. Red boxes mark the HAMLET parameter that modifies ELN risk. Except for aneuploidies and complex karyotypes, HAMLET provides all information required for risk assessment. Arrows point from a diagnostic sample to the relapse in the same patient. AML with MDS AML with myelodysplasia-associated changes, tAML therapy-related AML, Mut mutated, AML NOS AML not otherwise specified, ELN European leukemia net.