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. 2020 Oct 13;40(1):28–45. doi: 10.1038/s41388-020-01498-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Proliferation profiles of PLC/PRF/5 PTPN13-overexpressing cells transiently transfected with pCDH-IGF2BP1 or the control and PTPN13 interference cells with stable IGF2BP1 knockdown by shRNA or the control were analyzed by cell cycle analysis. B Proliferation profiles of the indicated cells described in (A) were analyzed by colony formation analysis. C Proliferation profiles of the indicated cells described in (A) were analyzed by an EdU assay. D Proliferative capacity in vivo of PTPN13 interference cells with stable IGF2BP1 knockdown by shRNA or the control were analyzed by subcutaneous tumor formation in nude mice. E The remaining c-Myc mRNA expression was measured after treatment with actinomycin D (Act. D) and the knockdown or overexpression of PTPN13 or IGF2BP1 in PLC/PRF/5 cells. F The GSH level and GSH/GSSG ratio were determined in Huh7 cells expressing siRNAs targeting IGF2BP1 or PTPN13, stable IGF2BP1 knockdown cells with c-Myc overexpression, and stable PTPN13 knockdown cells with IGF2BP1 knockdown by shRNAs. The data represent the mean ± SD of three independent experiments (*P < 0.05, **P < 0.01, ***P < 0.001; ns not significant).