Abstract
Covid-19 pandemic has caused hundreds of thousands deaths and millions of infections and continued spreading violently. Although researchers are racing to find or develop effective drugs or vaccines, no drugs from modern medical system have been proven effective and the high mutant rates of the virus may lead it resistant to whatever drugs or vaccines developed following modern drug development procedure. Current evidence has demonstrated impressive healing effects of several Chinese medicines (CMs) for Covid-19, which urges us to reflect on the role of CM in the era of modern medicine. Undoubtedly, CM could be promising resources for developing drug candidates for the treatment of Covid-19 in a way similar to the development of artemisinin. But the theory that builds CM, like the emphasis of driving away exogenous pathogen (virus, etc.) by restoring self-healing capacity rather than killing the pathogen directly from the inside and the ‘black-box’ mode of diagnosing and treating patients, is as important, yet often ignored, an treasure as CM herbs and should be incorporated into modern medicine for future advancement and innovation of medical science.
Keywords: Chinese medicine, Covid-19, SARS-CoV-2, coronavirus, herbal medicine
Footnotes
Competing Interests
The authors claimed no competing interests.
References
- 1.COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). https://coronavirus.jhu.edu/map.html, (accessed on 25th Sep, 2020)
- 2.Cavalcanti AB, Zampieri FG, Rosa RG, Azevedo LCP, Veiga VC, Avezumet A, et al. N Engl J Med. 2020. Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382:1787–1799. doi: 10.1056/NEJMoa2001282. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Joyner MJ, Senefeld JW, Klassen SA, Mills JR, Johnson PW, Theel ES, et al. MedRxiv. 2020. Effect of convalescent plasma on mortality among hospitalized patients with COVID-19: initial three-month experience; pp. 2020–2028. [Google Scholar]
- 5.Luo H, Tang QL, Shang YX, Liang SB, Yang M, Robinson N, et al. Can Chinese medicine be used for prevention of corona virus disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs. Chin J Integr Med. 2020;26:243–250. doi: 10.1007/s11655-020-3192-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Zhang MM, Liu XM, He L. Effect of integrated traditional Chinese and Western medicine on SARS: A review of clinical evidence. World J Gastroenterol. 2004;10:3500–3505. doi: 10.3748/wjg.v10.i23.3500. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Wang C, Cao B, Liu QQ, Zou ZQ, Jiang LD. Oseltamivir compared with the Chinese traditional therapy maxingshiganyinqiaosan in the treatment of H1N1 influenza: a randomized trial. Ann Intern Med. 2011;155:217–225. doi: 10.7326/0003-4819-155-4-201108160-00005. [DOI] [PubMed] [Google Scholar]
- 8.Chen CJ, Michaelis M, Hsu HK, Tsai CC, Yang KD, Wu YC, et al. Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication. J Ethnopharmacol. 2008;120:108–111. doi: 10.1016/j.jep.2008.07.048. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Press conference of the joint prevention and control of the state council. March 2020. http://www.china.com.cn/zhibo/content_75821573.htm (accessed on 24th Sep, 2020).
- 10.Chen G, Su W, Yang J, Luo D, Xia P, Jia W, et al. Front Med. 2020. Chinese herbal medicine reduces mortality in patients with severe and critical Coronavirus disease 2019: a retrospective cohort study. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Li RF, Hou YL, Huang JC, Pan WQ, Ma QH, Shi YX, et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2) Pharmacol Res. 2020;156:104761. doi: 10.1016/j.phrs.2020.104783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Hu K, Guan W J, Bi Y, Zhang W, Li L, Zhang B, et al. Phytomedicine. 2020. Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial; p. 153242. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Zeng M, Li L, Wu Z. Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019 (COVID-19): Meta-analysis of randomized controlled trials. PLoS One. 2020;15:e238828. doi: 10.1371/journal.pone.0238828. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Hu C, Liang M, Gong F, He B, Zhao D, Zhang G. Efficacy of Lianhua Qingwen compared with conventional drugs in the treatment of common pneumonia and COVID-19 pneumonia: A meta-analysis. Evid Based Complement Alternat Med. 2020;2020:5157089. doi: 10.1155/2020/5157089. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Duan C, Xia W, Zheng C, Sun G, Li Z, Li Q, et al. J Tradit Chin Med. 2020. Clinical observation of Jinhua Qinggan granule in treating novel coronavirus infection pneumonia. [Google Scholar]
- 16.Yin Q, Li C. Evid Complement Alternat Med. 2014. Treatment effects of Xuebijing injection in severe septic patients with disseminated intravascular coagulation; p. 2014. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Ma Q, Qiu M, Zhou H, Chen J, Yang X, Deng Z, et al. The study on the treatment of Xuebijing Injection (XBJ) in adults with severe or critical Corona Virus Disease 2019 and the inhibitory effect of XBJ against SARS-CoV-2. Pharmacol Res. 2020;160:105073. doi: 10.1016/j.phrs.2020.105073. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 18.Xiong WZ, Wang G, Du J, Ai W. Efficacy of herbal medicine (Xuanfei Baidu decoction) combined with conventional drug in treating COVID-19: A pilot randomized clinical trial. Integr Med Res. 2020;9:100489. doi: 10.1016/j.imr.2020.100489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Luo H, Gao Y, Zou J, Zhang S, Chen H, Liu Q, et al. Reflections on treatment of COVID-19 with traditional Chinese medicine. Chin Med. 2020;15:94. doi: 10.1186/s13020-020-00375-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Xin S, Cheng X, Zhu B, Liao X, Yang F, Song L, et al. Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment. Biomed Pharmacother. 2020;129:110500. doi: 10.1016/j.biopha.2020.110500. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Zhang L, Fan H, Chen R, Zhu X, Wang W, Cui D, et al. Discuss the rational application of Qingfei paidu decoction from clinical practice. J Tradit Chin Med. 2020;61:1573–1577. [Google Scholar]
- 22.Xiong X, Wang P, Su K, Cho WC, Xing Y. Chinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysis. Pharmacol Res. 2020;160:105056. doi: 10.1016/j.phrs.2020.105056. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Zheng S, Baak JP, Li S, Xiao W, Ren H, Yang H, et al. Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in corona virus disease, 2019 (COVID-19), gives fundamental support to the clinical use of LHQW. Phytomedicine. 2020;79:153336. doi: 10.1016/j.phymed.2020.153336. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Kageyama Y, Aida K, Kawauchi K, Morimoto M, Ebisui T, Akiyama T, et al. MedRxiv. 2020. Jinhua Qinggan Granule, a Chinese herbal medicine against COVID-19, induces rapid changes in the plasma levels of IL-6 and IFN-γ; pp. 2020–2026. [Google Scholar]
- 25.Wang Y, Li X, Zhang J, Xue R, Qian J, Zhang X, et al. China J Chin Mater Med. 2020. Mechanism of Xuanfei Baidu Tang in treatment of novel coronavirus pneumonia based on network pharmacology; pp. 1–9. [DOI] [PubMed] [Google Scholar]
- 26.Tao Q, Du J, Li X, Zeng J, Tan B, Xu J, et al. Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19. Drug Dev Ind Pharm. 2020;46:1345–1353. doi: 10.1080/03639045.2020.1788070. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 27.Huang Y F, Bai C, He F, Xie Y, Zhou H. Review on the potential action mechanisms of Chinese medicines in treating coronavirus disease 2019 (COVID-19) Pharmacol Res. 2020;158:104939. doi: 10.1016/j.phrs.2020.104939. [DOI] [PMC free article] [PubMed] [Google Scholar]