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. Author manuscript; available in PMC: 2022 Jan 7.
Published in final edited form as: Structure. 2020 Oct 15;29(1):50–60.e4. doi: 10.1016/j.str.2020.09.013

Fig. 3. Positioning of myosin pathological variants at the cardiac actomyosin interface.

Fig. 3

(A) Atomic model of the cardiac actomyosin complex shows structural elements of cardiac myosin involved in interactions with actin and tropomyosin: CM loop (blue ribbons), loop 2 (red ribbons), loop 4 (yellow ribbons), HLH motif (cyan ribbons), and loop 3 (brown ribbons). Actin atoms are tan, tropomyosin is black, while myosin motor domain is plum. (B-G) Myosin pathogenic variants are in magenta, while residues involved in interaction with those variants are in green. The proposed interactions are indicated with colored arrows. Pathogenic variants are shown for CM loop (B), loop 2 (C), loop 4 (D), HLH motif (E and F), and loop 3 (G).