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. 2021 Jan 7;9:e10675. doi: 10.7717/peerj.10675

Figure 5. SK and its derivatives suppressed pro-inflammatory cytokines and promoted anti-inflammatory cytokine in serum.

Figure 5

(A–D) The protein level of cytokines IL-6, IL-1β, TNF-α and IL-10 in serum were determined by ELISA (DSS: 3.5%; SK, Naphthoquinone, β, β-dimethylacryl-SK, Acetyl-SK, AK: 25 mg/kg; Mesalazine: 200 mg/kg). (E–H) Effects of different concentrations of SK on the levels of cytokines IL-6, IL-1β, TNF-α and IL-10. Data are shown as mean ± S.E.M, *p < 0.05, **p < 0.01 versus control group; # p < 0.05, ## p < 0.01 versus DSS-treated group (n = 6 per group).