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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2020 Nov 29:jiaa744. doi: 10.1093/infdis/jiaa744

Levels of Soluble CD14 and Tumor Necrosis Factor Receptors 1 and 2 may be predictive of death in Severe Coronavirus Disease 2019 (COVID-19)

Emily R Bowman 1,1, Cheryl M Ainslie Cameron 2,1, Ann Avery 3,4, Janelle Gabriel 1, Aaren Kettelhut 1, Michelle Hecker 3,4, Claudia Ute Sontich 3, Banumathi Tamilselvan 2, Carmen N Nichols 5, Brian Richardson 2,5, Michael Cartwright 5, Nicholas T Funderburg 1,2,, Mark J Cameron 5,2,
PMCID: PMC7799002  PMID: 33249506

Abstract

People infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) display a wide range of illness, from asymptomatic infection to severe respiratory distress resulting in death. We measured serum biomarkers in uninfected individuals and in individuals with mild, moderate, or critical COVID-19 disease. Levels of monocyte activation (sCD14 and FABP4) and inflammation (TNFR1 and 2) were increased in COVID-19 individuals, regardless of disease severity. Among patients with critical disease, individuals who recovered from COVID-19 had lower levels of TNFR1 and TNFR2 at hospital admission compared to these levels in patients with critical disease that ultimately died.

Keywords: SARS-CoV-2, monocytes, tumor necrosis factor, COVID-19


Articles from The Journal of Infectious Diseases are provided here courtesy of Oxford University Press

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