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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2020 Dec 2:piaa161. doi: 10.1093/jpids/piaa161

SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19

Elizabeth M Anderson 1,#, Caroline Diorio 2,3,#, Eileen C Goodwin 1, Kevin O McNerney 2,3, Madison E Weirick 1, Sigrid Gouma 1, Marcus J Bolton 1, Claudia P Arevalo 1, Julie Chase 2,4, Philip Hicks 1,5, Tomaz B Manzoni 1, Amy E Baxter 6,7, Kurt P Andrea 6,7, Chakkapong Burudpakdee 2, Jessica H Lee 2, Laura A Vella 6,7,8, Sarah E Henrickson 9, Rebecca M Harris 10, E John Wherry 6,7, Paul Bates 1,11, Hamid Bassiri 2,8, Edward M Behrens 2,4, David T Teachey 2,3, Scott E Hensley 1,
PMCID: PMC7799010  PMID: 33263756

Abstract

SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients.

Keywords: COVID-19, Pediatric, Antibodies, Multisystem Inflammatory Syndrome in Children (MIS-C), SARS-COV-2


Articles from Journal of the Pediatric Infectious Diseases Society are provided here courtesy of Oxford University Press

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