Fig. 1.

Schematic representation of functional domains for MITF family members and TFEB target genes. (a), MITF members contain N-term transcriptional activation domain (AD), basic helix-loop-helix region (bHLH), leucine zipper (LZ), proline-rich domain (Pro-rich), or serine-rich stretch (Ser) domain. Numbers indicate amino acid location in the protein. (b), Diagram illustrating the genes and pathways regulated by TFEB. Besides autophagy and lysosomal biogenesis genes, TFEB also regulates numerous other genes and pathways. Abbreviations: ECs, endothelial cells; VSMCs, vascular smooth muscle cells; TAMs, tumor-associated macrophages.